Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ugurel, S; Reinhold, U; Tilgen, W.
HLA-G in melanoma: A new strategy to escape from immunosurveillance?
Onkologie. 2002; 25(2):129-134
Doi: 10.1159/000055222
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- Führende Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- The non-classical HLA class-I molecule HLA-G, primarily expressed on fetal cells of the human placenta, has been shown to play a crucial role in maintaining an immuno-privileged environment at the materno-fetal interface. Fetal trophoblast cells are protected from attack by CD8+ cytotoxic T lymphocytes due to their lacking expression of classical HLA class-I molecules, again rendering them susceptible to natural killer (NK) cell lysis. HLA-G has been shown to interact with killing inhibitory receptors, hereby rescuing the fetal placenta cells from NK cell attack. Likewise, classical HLA class-I molecules are known to be frequently downregulated or lost during the development of malignancies. This abnormality is often associated with a poor clinical course of disease, despite of the frequent detection of tumor-infiltrating NK cells. This controversy seemed to be resolved with the detection of HLA-G expression on cells of malignant melanoma and other solid tumors. Since interferon(IFN)s are known for their ability of upregulation or induction of HLA-G expression, the potential function of HLA-G as a new strategy of cancer cells to escape from immunosurveillance might be of particular importance in malignant melanoma. The frequent use of IFN-alpha in the immunotherapy of this malignancy might possibly worsen the already impaired antitumoral immune response state of melanoma patients. However, several studies recently failed to detect any HLA-G protein expression in cancer cell lines and tissues of different origin, particularly in malignant melanoma, yet rendering the expression and function of HLA-G in malignancies as a possibly overrated matter of controversial debate.
- Find related publications in this database (using NLM MeSH Indexing)
- HLA Antigens - physiology
- Histocompatibility Antigens Class I - physiology
- Humans -
- Immunologic Surveillance - immunology
- Immunotherapy -
- Interferon-alpha - adverse effects Interferon-alpha - therapeutic use
- Melanoma - drug therapy Melanoma - immunology
- Prognosis -
- Skin Neoplasms - drug therapy Skin Neoplasms - immunology
- Tumor Escape - immunology
- Up-Regulation - immunology
- Find related publications in this database (Keywords)
- HLA-G
- HLA class-I
- NK cells
- malignant melanoma