Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pföhler, C; Steinhäuser, S; Wagner, A; Ugurel, S; Tilgen, W.
Complete remission of cutaneous satellite and in-transit metastases. After intralesional therapy with interleukin-2 in 2 patients with malignant melanoma.
Hautarzt. 2004; 55(2):171-175
Doi: 10.1007/s00105-003-0620-4
(- Case Report)
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Multiple cutaneous satellite and in-transit metastases of melanoma without involvement of lymph nodes or other organs are a challenge especially when they occur in elderly inoperable patients with multiple internal diseases. In this particular situation, intralesional application of interleukin-2 may represent an effective alternative to systemic chemo- or immunotherapy as it can be performed on an out-patient basis and has few side effects. We treated two elderly female patients with multiple cutaneous metastases of malignant melanoma with intra- and perilesional application of interleukin-2 (3 x 6-12 Mio IE) over 12 weeks and achieved a complete remission of these metastases. In follow-up biopsies, no viable tumor cells were found. Despite a slight burning at the injection side and a transient local inflammatory reaction, the therapy was well tolerated in both cases after premedication with paracetamol 500 mg orally and pretreatment of the injection site with a cream containing lidocaine and prilocaine. No systemic side effects were observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Antineoplastic Agents - administration and dosage
- Biopsy -
- Female -
- Follow-Up Studies -
- Humans -
- Injections, Intralesional -
- Interleukin-2 - administration and dosage
- Melanoma - drug therapy Melanoma - pathology
- Neoplasm Metastasis -
- Remission Induction -
- Skin - pathology
- Skin Neoplasms - drug therapy Skin Neoplasms - pathology
- Time Factors -
- Find related publications in this database (Keywords)
- malingnant melanoma
- intralesional therapy
- interleukin-2