Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fink, W; Zimpfer, A; Ugurel, S.
Mucosal metastases in malignant melanoma.
Onkologie. 2003; 26(3):249-251
Doi: 10.1159/000071620
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Background: We present the case of a patient with malignant melanoma stage IV according to the American Joint Committee on Cancer (AJCC) classification and an unusual pattern of metastasis to the mucosa of the esophagus, the stomach, the bladder and the palatine tonsil. Case Report: A 38-year-old male patient with metastatic malignant melanoma of stage III (AJCC) was admitted for initiation of adjuvant therapy. 4 months earlier a primary melanoma of the left upper leg had been excised and 2 months later the patient had undergone a left inguinal lymph node dissection revealing 2 metastatic lymph nodes. On admission the patient complained of a sore throat and right cervical lymphadenopathy. He underwent a tonsillectomy and a lymphadenectomy which both revealed melanoma metastases. A PET scan using F-18-fluorodeoxyglucose (FDG) showed focal metabolic activity in the middle mediastinum. Two cycles of dacarbazine (DTIC) chemotherapy were performed during which the patient developed cutaneous metastases, dyspepsia, and mild hematemesis. Gastroscopy revealed bleeding from mucosal metastases of the esophagus and stomach. A few weeks later the patient developed macroscopic hematuria. A cystoscopy was performed and showed metastases to the mucosa of the bladder. Nutrient vessels of these bladder metastases were embolized in order to control bleeding. The patient is currently alive with progressive disease. Results: This case presents common and uncommon sites of metastatic melanoma to the mucosa with the typical clinical manifestations in a single patient.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Combined Modality Therapy -
- Diagnosis, Differential -
- Esophageal Neoplasms - pathology Esophageal Neoplasms - secondary Esophageal Neoplasms - therapy
- Gastric Mucosa - pathology
- Humans -
- Male -
- Melanoma - pathology Melanoma - secondary Melanoma - therapy
- Mucous Membrane - pathology
- Neoplasm Staging -
- Skin Neoplasms - pathology Skin Neoplasms - therapy
- Stomach Neoplasms - pathology Stomach Neoplasms - secondary Stomach Neoplasms - therapy
- Tomography, Emission-Computed -
- Tonsillar Neoplasms - pathology Tonsillar Neoplasms - secondary Tonsillar Neoplasms - therapy
- Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - secondary Urinary Bladder Neoplasms - therapy
- Find related publications in this database (Keywords)
- metastatic malignant melanoma
- mucosal metastasis
- hematemesis
- hematuria