Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

Ugurel, S; Rappl, G; Tilgen, W; Reinhold, U.
Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival.
J Clin Oncol. 2001; 19(2):577-583 Doi: 10.1200/JCO.2001.19.2.577 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

Führende Autor*innen der Med Uni Graz: Ugurel-Becker Selma
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Purpose: To determine the predictive value of the angiogenic serum factors angiogenin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and interleukin-8 (IL-8) for the prognosis of patients with malignant melanoma. Patients and Methods: Angiogenin,VEGF, bFGF,and IL-8 were measured in sera of 125 melanoma patients with different stages of disease and with or without current therapy including interferon alfa and different cytostatics in comparison with 30 healthy controls using enzyme-linked immunosorbent assay. Results: Serum levels of angiogenin, VEGF, bFGF, and IL-8 were significantly increased in melanoma patients compared with healthy controls. Elevated serum concentrations of VEGF, bFGF, and IL-8 were associated with advanced disease stages and tumor burden. Cytostatic therapy of patients was accompanied by increased serum levels of angiogenin, bFGF, and IL-8. As shown by univariate analysis, elevated serum levels of VEGF (P =.0001 and .0036), bFGF (P <.00005 and <.00005), and IL-8 (P <.00005 and <.00005) were strongly correlated with a poor overall and progression-free survival, respectively. Multivariate analysis revealed stage of disease (P =.0238), tumor burden (P =.0447), VEGF (P =.0036), bFGF (P =.0252), and IL-8 (P =.0447) as independent predictive factors of overall survival. Tumor burden (P =.0081), VEGF (P =.0245), and IL-8 (P =.0089) were found as independent predictive factors of progression-free survival. Conclusion: Our data suggest that the angiogenic serum factors VEGF, bFGF, and IL-8 are useful predictive markers for overall and progression-free survival in melanoma patients. J Clin Oncol 19:577-583. (C) 2001 by American Society of Clinical Oncology.
Find related publications in this database (using NLM MeSH Indexing): Analysis of Variance -; Angiogenesis Inducing Agents - blood; Biological Markers - blood; Endothelial Growth Factors - blood; Female -; Fibroblast Growth Factor 2 - blood; Growth Substances - blood; Humans -; Interleukin-8 - blood; Lymphokines - blood; Male -; Melanoma - blood Melanoma - mortality Melanoma - pathology; Middle Aged -; Neoplasm Proteins - blood; Neoplasm Staging -; Predictive Value of Tests -; Prognosis -; Proportional Hazards Models -; Ribonuclease, Pancreatic - blood; Survival Analysis -; Vascular Endothelial Growth Factor A -; Vascular Endothelial Growth Factors -