Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Seiter, S; Ugurel, S; Tilgen, W; Reinhold, U.
High-dose pulse corticosteroid therapy in the treatment of severe alopecia areata.
Dermatology. 2001; 202(3):230-234
Doi: 10.1159/000051642
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Objective: The present monocenter prospective study was designed to evaluate the efficacy of intravenous high-dose methylprednisolone pulse therapy in patients with severe alopecia areata (AA). Methods: 30 patients (aged 14-56 years) were treated with methylprednisolone (8 mg/kg body weight) intravenously on 3 consecutive days at 4-week intervals for at least 3 courses. Results: 67% of patients with AA plurifocalis showed >50% regrowth of hair. None of the patients with AA totalis or universalis and only 1 patient with ophiasic AA responded to therapy. In patients with AA plurifocalis, higher response rates could be observed in those suffering from long-term disease compared to patients treated during their first episodes of AA (73 vs. 57%). Conclusion: High-dose methylprednisolone pulse therapy is an effective and well-tolerated treatment for patients with severe AA plurifocalis but might be less beneficial for patients with ophiasic AA, AA totalis or universalis. Copyright (C) 2001 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Alopecia Areata - drug therapy Alopecia Areata - pathology
- Anti-Inflammatory Agents - administration and dosage Anti-Inflammatory Agents - adverse effects
- Fatigue - chemically induced
- Female -
- Follow-Up Studies -
- Hair - drug effects Hair - growth and development
- Headache - chemically induced
- Humans -
- Male -
- Methylprednisolone - administration and dosage Methylprednisolone - adverse effects
- Middle Aged -
- Nausea - chemically induced
- Prospective Studies -
- Pulse Therapy, Drug -
- Tachycardia - chemically induced
- Treatment Outcome -
- Find related publications in this database (Keywords)
- high-dose corticosteroid pulse therapy
- alopecia areata
- monocenter prospective study