Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eller, K; Weber, T; Pruenster, M; Wolf, AM; Mayer, G; Rosenkranz, AR; Rot, A.
CCR7 deficiency exacerbates injury in acute nephritis due to aberrant localization of regulatory T cells.
J Am Soc Nephrol. 2010; 21(1):42-52
Doi: 10.1681/ASN.2009020133
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Rosenkranz Alexander
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- Abstract:
- The homing of dendritic cells and T cells to secondary lymphoid organs requires chemokine receptor 7 (CCR7) expression on these cells. T cells mediate the pathogenesis of experimental accelerated nephrotoxic serum nephritis (NTS), including its suppression by regulatory T cells (Tregs), but the contribution of CCR7 to this disease is unknown. Here, we compared the development of NTS in CCR7-knockout (KO) and wild-type (WT) mice. Compared with WT mice, CCR7KO mice developed more severe disease with significantly more inflammatory cells infiltrating the kidney. These cells included FoxP3(+) Tregs, which were virtually absent from WT kidneys. The adoptive transfer of WT Tregs into CCR7KO mice at the time of immunization protected the recipients from disease; these cells homed to secondary lymphoid organs but not to kidneys. Conversely, adoptive transfer of CCR7KO Tregs into WT mice did not inhibit development of NTS. These data suggest that NTS can develop without CCR7 expression, but Treg-mediated disease suppression, which seems to occur in secondary lymphoid organs, requires CCR7.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Animals -
- Cell Movement - physiology
- Cytokines - metabolism
- Disease Models, Animal -
- Down-Regulation - physiology
- Immune System - physiopathology
- Kidney - metabolism Kidney - pathology
- Lymph Nodes - metabolism Lymph Nodes - pathology
- Mice -
- Mice, Inbred BALB C -
- Mice, Knockout -
- Nephritis - metabolism Nephritis - pathology Nephritis - physiopathology
- Receptors, CCR7 - genetics Receptors, CCR7 - metabolism
- Severity of Illness Index -
- T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology