Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eller, P; Eller, K; Wolf, AM; Reinstadler, SJ; Tagwerker, A; Patsch, JR; Mayer, G; Rosenkranz, AR.
Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis.
Kidney Int. 2010; 77(5):428-435
Doi: 10.1038/ki.2009.478
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Eller Philipp
- Co-Autor*innen der Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- Statins mediate many of their protective effects by lowering lipids as well as by modulating inflammation. Here, we studied their potential immunomodulatory role in renal inflammation using an autoimmune mouse model of anti-glomerular basement membrane glomerulonephritis. Oral treatment with Atorvastatin dramatically reduced albuminuria and histological changes in the kidneys as compared to vehicle-treated control animals. There was a significant decrease in the Th1 and Th17 response in the regional lymph nodes draining the kidneys. This systemic effect was accompanied by decreased infiltration of the kidneys with inflammatory CD4(+) T and Th17 cells, macrophages, and neutrophils in statin-treated mice. Regulatory T cells were not altered in their number, FoxP3 expression, or suppressive capacity, but their interleukin-10 production was significantly increased by statin treatment. Hence, Atorvastatin systemically and locally decreased the Th1 and Th17 response, thereby protecting the mice against anti-glomerular basement membrane glomerulonephritis. Whether statins can be used to treat human autoimmune renal diseases will require more direct studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- CD4-Positive T-Lymphocytes - immunology
- Glomerular Basement Membrane - immunology Glomerular Basement Membrane - pathology
- Glomerulonephritis - immunology Glomerulonephritis - metabolism Glomerulonephritis - pathology
- Heptanoic Acids - immunology Heptanoic Acids - metabolism
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - immunology Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism
- Immunohistochemistry -
- Interleukin-10 - immunology Interleukin-10 - metabolism
- Kidney Glomerulus - immunology Kidney Glomerulus - metabolism
- Male -
- Mice -
- Mice, Inbred C57BL -
- Pyrroles - immunology Pyrroles - metabolism
- T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
- Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - physiology
- Find related publications in this database (Keywords)
- glomerulonephritis
- immunology and pathology
- statins