Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Joannidis, M; Rauchenzauner, M; Leiner, B; Rosenkranz, A; Ebenbichler, CF; Laimer, M; Tatarczyk, T; Meusburger, E; Mayer, G.
Effect of intradialytic parenteral nutrition in patients with malnutrition-inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results from a pilot study.
Eur J Clin Nutr. 2008; 62(6):789-795
Doi: 10.1038/sj.ejcn.1602777
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- Objective: Evaluation of the influence of intradialytic parenteral nutrition (IDPN) in patients suffering from Malnutrition Inflammation Complex Syndrome (MICS) on nutritional status, inflammation, adipocytokines and serum lipids. Subjects: Six patients with MICS were assigned to IDPN, whereas six patients matched for age, sex, body mass index (BMI) and co-morbidity without malnutrition served as controls. Patients were recruited from Outpatient Dialysis Unit, Medical University Innsbruck and from Dialysis Unit, Hospital Feldkirch. Results: In all patients with IDPN, dry body weight increased during the interventional period whereas body weight remained stable in patients without IDPN. Tumor necrosis factor (TNF)-alpha levels were higher in patients with MICS compared with controls at all time points. Total cholesterol, LDL-and HDL-levels significantly increased during dialysis at all time points in controls but not in patients with MICS. Albumin, C-reactive protein, interleukin-6 (IL-6), soluble interleukin-2 receptor (sIL-2R) and adipocytokines did not differ between patients and controls during the study period. Conclusions: IDPN in patients with MICS increases body weight despite not influencing inflammatory status. Furthermore, IDPN does not induce a pro-atherogenic lipid composition enhancing the risk for atherosclerosis. Thus, IDPN is a safe and effective treatment of malnutrition in patients with MICS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipokines - blood
- Aged -
- Aged, 80 and over -
- C-Reactive Protein - metabolism
- Cholesterol - blood
- Cohort Studies -
- Female -
- Humans -
- Inflammation - blood Inflammation - immunology Inflammation - therapy
- Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy
- Lipids - blood
- Male -
- Malnutrition - blood Malnutrition - therapy
- Nutritional Requirements -
- Nutritional Status -
- Parenteral Nutrition - methods
- Pilot Projects -
- Prospective Studies -
- Renal Dialysis - methods
- Serum Albumin - metabolism
- Treatment Outcome -
- Weight Gain -
- Find related publications in this database (Keywords)
- MICS
- intradialytic parenteral nutrition
- hemodialysis