Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Combes, V; Rosenkranz, AR; Redard, M; Pizzolato, G; Lepidi, H; Vestweber, D; Mayadas, TN; Grau, GE.
Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment.
Am J Pathol. 2004; 164(3):781-786
Doi: 10.1016/S0002-9440(10)63166-5
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- Co-Autor*innen der Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- P-selectin is a leukocyte adhesion receptor expressed on the surface of activated platelets and endothelial cells. Its role in the pathogenesis of cerebral malaria was explored in a murine model of cerebral malaria. Infection of mice with Plasmodium berghei ANKA led to P-selectin up-regulation in brain vessels of cerebral malaria-susceptible mice but not of cerebral malaria-resistant mice. Treatment of susceptible mice with anti-mouse P-selectin mAb failed to prevent the development of the neurological syndrome. However, P-selectin-deficient mice infected with Plasmodium berghei ANKA had a cumulative incidence of cerebral malaria which was significantly reduced compared to wild-type animals (4.5% versus 80%, respectively), despite identical levels of parasitemia, platelet and leukocyte accumulation. To determine whether P-selectin on platelets and/or endothelium was responsible for the microvascular pathology, cerebral malaria was assessed in chimeric mice deficient in platelet or endothelial P-selectin, which were generated by bone marrow transplantation. Mice deficient only in endothelial P-selectin did not show any sign of cerebral malaria (vascular plugging, hemorrhages, or edema), while mice lacking only platelet P-selectin showed signs of cerebral malaria similar to that seen in wild-type mice. These results indicate that endothelial P-selectin plays an important role in the pathogenesis of cerebral malaria.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Platelets - physiology
- Brain - blood supply Brain - pathology
- Disease Models, Animal -
- Endothelium, Vascular - physiology
- Female -
- Image Processing, Computer-Assisted -
- Immunohistochemistry -
- Lung - blood supply Lung - pathology
- Malaria, Cerebral - pathology
- Mice -
- Mice, Knockout -
- P-Selectin - physiology
- Plasmodium berghei -