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Selected Publication:
KOLLER, DY; ROSENKRANZ, AR; PIRKER, C; GOTZ, M; JARISCH, R.
Assessment of histamine release from basophils in whole blood by benzylpenicilloyl poly-L-lysine in penicillin-sensitized patients.
Allergy. 1992; 47(5):459-462
Doi: 10.1111/j.1398-9995.1992.tb00664.x
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- Co-authors Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- Histamine release from basophil granulocytes in whole blood by benzylpenicilloyl poly-L-lysine (PPL) was investigated in 7 patients with penicillin allergy. All patients presented with systemic immediate hypersensitivity reactions after i.v. administration of penicillin G. Total histamine (of 7 patients) ranged from 27.5 ng/ml to 62.1 ng/ml (mean 43.2 ng/ml). The spontaneous histamine release ranged from 0.15% to 5.1% (mean 1.8%) of the total content. Addition of PPL in various concentrations resulted in values between 0.8 and 9.6%. Although PPL is a reliable allergen for prick- and intradermal testing in the diagnosis of penicillin allergy--demonstrating a histamine liberation in the skin--the in vitro experiment using the same allergen showed no histamine release above 10%. Using a threshold of 5% out of 7 patients, 4 (57%) would show a positive histamine release. Therefore it might indicate that in penicillin allergy a threshold of 5% must be used. In addition, basophils in whole blood and skin mast cells may be activated differently.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Basophils - drug effects Basophils - metabolism
- Benzeneacetamides -
- Drug Eruptions - diagnosis Drug Eruptions - etiology
- Histamine Release - drug effects Histamine Release - immunology
- Humans -
- Immunoglobulin E - analysis Immunoglobulin E - immunology
- Middle Aged -
- Penicillin G - analogs and derivatives Penicillin G - diagnostic use
- Penicillins - adverse effects
- Polylysine - diagnostic use
- Find related publications in this database (Keywords)
- BASOPHILS
- BENZYLPENICILLOYL POLY-L-LYSINE
- DIAGNOSIS
- HISTAMINE RELEASE
- PENICILLIN ALLERGY