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Selected Publication:
Thalhammer, F; Schmaldienst, S; Elmenyawi, I; Atteneder, M; Burgmann, H; Hollenstein, U; Georgopoulos, A; Graninger, W; Putz, D; Rosenkranz, AR; Mayer, G; Horl, WH; Breyer, S.
Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes.
Clin Pharmacol Ther. 1996; 60(6):645-650
Doi: 10.1016/S0009-9236(96)90212-X
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- Co-authors Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- Cefpirome is a cephalosporin eliminated primarily by kidneys that requires dosage reduction in patients with renal failure. The pharmacokinetic parameters were studied in 10 patients with end-stage renal disease who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12.2 +/- 5.4 micrograms/ml and peak serum concentrations of 99.6 +/- 82.1 micrograms/ml. After 3 1/2 hours of hemodialysis with polysulfone high-flux membranes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half-life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Cephalosporins - administration and dosage Cephalosporins - blood Cephalosporins - pharmacokinetics
- Chromatography, High Pressure Liquid -
- Female -
- Humans -
- Infusions, Intravenous -
- Kidney Failure, Chronic - therapy
- Male -
- Membranes, Artificial -
- Middle Aged -
- Polymers -
- Renal Dialysis - methods
- Sulfones -