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Selected Publication:
Thalhammer, F; Kletzmayr, J; El Menyawi, I; Kovarik, J; Rosenkranz, AR; Traunmuller, F; Horl, WH; Burgmann, H.
Ofloxacin clearance during hemodialysis: a comparison of polysulfone and cellulose acetate hemodialyzers.
Am J Kidney Dis. 1998; 32(4):642-645
Doi: 10.1016/S0272-6386(98)70029-0
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- Co-authors Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- The pharmacokinetics of ofloxacin were studied in 13 patients with end-stage renal disease during hemodialysis using two different dialyzers: a polysulfone membrane (Fresenius F6) and a cellulose acetate dialyzer (Nissho Nipro FB-150T). All patients received 100 mg ofloxacin orally per day before dialysis. The hemodialysis clearance per square meter surface area was significantly different, with 5.0+/-0.7 L/h and 3.7+/-1.6 L/h, respectively. The serum concentration was reduced by a 3-hour hemodialysis by 49.6%+/-5.8% per square meter surface area and 45.5%+/-4.8% per square meter surface area. The half-life was 4.2+/-1.8 hours and 4.8+/-1.6 hours during the hemodialysis period and 22.8+/-2.2 hours and 23.3+/-1.7 hours between the dialysis sessions, respectively. Comparing polysulfone and cellulose acetate dialyzers, the material of the membrane influences the half-life, the dialysis clearance, and the percentage of drug extracted during hemodialysis. We conclude that the type of dialyzer used has to be taken into account in dosage recommendations for antimicrobial therapy in hemodialysis patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anti-Infective Agents - blood Anti-Infective Agents - pharmacokinetics
- Biocompatible Materials -
- Cellulose - analogs and derivatives
- Humans -
- Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy
- Membranes, Artificial -
- Middle Aged -
- Ofloxacin - blood Ofloxacin - pharmacokinetics
- Polymers -
- Renal Dialysis - instrumentation
- Sulfones -
- Find related publications in this database (Keywords)
- ofloxacin
- hemodialysis
- pharmacokinetics
- polysulfone
- cellulose acetate