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Selected Publication:
Rosenkranz, AR; Coxon, A; Maurer, M; Gurish, MF; Austen, KF; Friend, DS; Galli, SJ; Mayadas, TN.
Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.
J IMMUNOL. 1998; 161(12): 6463-6467.
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- Rosenkranz Alexander
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- Abstract:
- Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration. We demonstrate that Mac-1 is also expressed on peritoneal mast cells and LPS stimulated bone marrow-derived cultured mast cells, and that Mac-1-deficient mice, which lack this receptor, have significant reductions in the numbers of mast cells resident in the peritoneal cavity, peritoneal wall, and dorsal skin. The reduced numbers of mast cells in Mac-1-deficient mice may have important functional consequences, in that Mac-1-deficient mice exhibit significantly increased mortality after cecal ligation and puncture, a model of acute septic peritonitis in which host resistance has been shown to be dependent on both mast cells and complement. These findings demonstrate that Mac-1 is required for the expression of normal levels of mast cells in the peritoneal cavity, peritoneal wall, and certain areas of the skin, as well as for maintaining adequate mast cell-dependent host defense against bacterial infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Animals -
- Cell Count -
- Immunity, Innate -
- Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - pathology
- Intestinal Mucosa - immunology Intestinal Mucosa - pathology
- Intestinal Perforation - complications
- Macrophage-1 Antigen - genetics Macrophage-1 Antigen - physiology
- Male -
- Mast Cells - pathology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Peritoneal Cavity - pathology
- Peritonitis - complications Peritonitis - immunology Peritonitis - pathology
- Skin - pathology