Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mayadas, TN; Rosenkranz, A; Cotran, RS.
Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo.
Curr Opin Nephrol Hypertens. 1999; 8(3):293-298
Doi: 10.1097/00041552-199905000-00004
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- Co-Autor*innen der Med Uni Graz
- Rosenkranz Alexander
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- Abstract:
- Single gene knock-outs in mice have been used to define the biological role of leukocyte adhesion receptors, Fc-gamma receptors and complement in animal models of immune complex glomerulonephritis. These studies have shown important differences in the role of P-selectin in glomerular inflammation and inflammation at other sites, and have given a new appreciation of the dominant role played by Fc-gamma receptors in immune complex-induced glomerular injury.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Adhesion Molecules - genetics Cell Adhesion Molecules - physiology
- Complement System Proteins - physiology
- Disease Models, Animal -
- Glomerulonephritis - etiology Glomerulonephritis - genetics Glomerulonephritis - immunology
- Immune Complex Diseases - etiology Immune Complex Diseases - genetics Immune Complex Diseases - immunology
- Leukocytes - immunology
- Mice -
- Mice, Knockout -
- Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - physiology
- Selectins - genetics Selectins - physiology