Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rovaris, M; Rocca, MA; Barkhof, F; Calabrese, M; De Stefano, N; Khalil, M; Fazekas, F; Fisniku, L; Gallo, P; Miller, DH; Montalban, X; Polman, C; Rovira, A; Sombekke, MH; Sormani, MP; Stromillo, ML; Filippi, M.
Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study.
Mult Scler. 2011; 17(3): 319-326.
Doi: 10.1177/1352458510388824
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Khalil Michael
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- Abstract:
- Background and Objectives: We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course. Methods: In seven MAGNIMS centres we retrospectively identified 182 patients with benign (B) MS (EDSS score <= 3.0, disease duration >= 15 years) and 187 patients with non-disabling relapsing-remitting MS (NDRRMS) (Expanded Disability Status Scale score >= 3.0, disease duration between 5 and 14 years), in whom clinical data were collected within two weeks from a brain T2-weighted scan. Brain T2 lesion volume (LV) was measured in all patients. In 146 BMS and 146 NDRRMS patients, clinical data were also available after a median follow up of 29 months (range: 7-104 months). Results: Mean LV was higher in BMS than in NDRRMS patients (p < 0.001), but the mean ratio between LV and disease duration was higher in NDRRMS than in BMS patients (1.1 vs. 0.6 ml/year, p < 0.001). In BMS patients, brain LV was correlated with EDSS score increase at follow up (r=0.18, p=0.03). Conclusions: An overall low rate of brain LV increase during a long-lasting disease course might be a feature of BMS. In BMS patients, a high brain LV might be associated with worsening of locomotor disability at short-term follow up.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Brain - pathology
- Disability Evaluation -
- Disease Progression -
- Disease Progression -
- Female -
- Humans -
- Logistic Models -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Motor Activity -
- Multiple Sclerosis, Relapsing-Remitting - pathology Multiple Sclerosis, Relapsing-Remitting - physiopathology
- Predictive Value of Tests -
- Prognosis -
- Retrospective Studies -
- Severity of Illness Index -
- Time Factors -
- Find related publications in this database (Keywords)
- benign
- multiple sclerosis
- disability
- MRI
- multicentre