Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Martseniuk, OP; Romanets', KL; Obolens'ka, MIu; Huppertz, B.
Effect of homocysteine on the structure and functions of human placenta trophoblasts.
Ukr Biokhim Zh. 2010; 81(5): 40-49.
PubMed
- Führende Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Elevated level of homocysteine in blood serum of pregnant women is the risk factor for placental malfunction and fetal abnormalities. Our study has shown the activation of apoptosis, inhibition of proliferation, destruction of placental trophoblast and activation of the transsulfuration pathway under elevated homocysteine level in the incubation medium in the range of 20-80 microM. The activation of the transsulfuration pathway indicates that placenta may to some extent withstand elevated homocysteine level.
- Find related publications in this database (using NLM MeSH Indexing)
- Apoptosis - drug effects
- Cell Proliferation - drug effects
- Cystathionine beta-Synthase - genetics Cystathionine beta-Synthase - metabolism
- Female -
- Gene Expression - drug effects
- Homocysteine - metabolism Homocysteine - pharmacology
- Humans -
- Microscopy, Fluorescence -
- Organ Culture Techniques -
- Placenta - drug effects Placenta - enzymology Placenta - metabolism Placenta - ultrastructure
- Pregnancy -
- Pregnancy Trimesters -
- Sulfur - metabolism
- Trophoblasts - drug effects Trophoblasts - enzymology Trophoblasts - metabolism Trophoblasts - ultrastructure