Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Thonhofer, R; Hiller, M; Just, H; Trummer, M; Siegel, C; Dejaco, C.
Treatment of refractory adult-onset Still's disease with tocilizumab: report of two cases and review of the literature.
Rheumatol Int. 2011; 31(12): 1653-1656.
Doi: 10.1007/s00296-010-1631-y
(- Case Report)
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Dejaco Christian
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- Abstract:
- Adult-onset Still's disease (AOSD) is empirically treated with nonsteroidal anti-inflammatory drugs, corticosteroids, conventional disease-modifying antirheumatic drugs, tumor necrosis factor-blocking agents or anakinra. The monoclonal anti-interleukin (IL)-6 antibody tocilicumab (TOC) has recently been approved for the treatment of rheumatoid arthritis and may be an attractive therapeutic option for AOSD as well. We report two AOSD patients treated with TOC and review of the current data on the use of TOC in AOSD. TOC was applied to the first patient after failure of cloroquin, methotrexate, adalimumab and etanercept. The second patient received TOC because of inefficacious methotrexate treatment. TOC was well tolerated by both the patients, and no clinically significant side effects occurred. Including these two cases, a total of seven AOSD patients have been successfully treated with TOC so far. TOC may be a promising treatment option for AOSD patients refractory to conventional disease-modifying antirheumatic drugs anakinra and tumor necrosis factor-[Formula: see text].
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
- Antibodies, Monoclonal, Humanized - therapeutic use
- Drug Therapy, Combination -
- Female -
- Humans -
- Immunosuppressive Agents - therapeutic use
- Interleukin-6 - antagonists and inhibitors
- Methotrexate - therapeutic use
- Prednisolone - therapeutic use
- Still's Disease, Adult-Onset - diagnosis
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Adult-onset still's disease
- Tocilizumab
- Adalimumab
- Etanercept
- Methotrexate
- Interleukin-6
- Anakinra