Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gugatschka, M; Kiesler, K; Obermayer-Pietsch, B; Groselj-Strele, A; Griesbacher, A; Friedrich, G.
Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract.
Eur Arch Otorhinolaryngol. 2011; 268(8): 1201-1204.
Doi: 10.1007/s00405-010-1481-y
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Gugatschka Markus
- Co-Autor*innen der Med Uni Graz
- Friedrich Gerhard
- Griesbacher Antonia
- Groselj-Strele Andrea
- Kiesler Karl
- Obermayer-Pietsch Barbara
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- Abstract:
- Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged - epidemiology
- Carcinoma, Squamous Cell - blood
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Head and Neck Neoplasms - blood
- Humans -
- Male -
- Middle Aged -
- Morbidity - trends
- Prognosis -
- Retrospective Studies -
- Survival Rate - trends
- Time Factors -
- Tumor Markers, Biological - blood
- Vitamin D - blood
- Find related publications in this database (Keywords)
- Vitamin D status
- 25-Hydroxyvitamin D (25(OH)D)
- Head and neck squamous cell carcinoma (HNSCC)