Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Augustin, H; Sun, M; Isbarn, H; Pummer, K; Karakiewicz, P.
Decision curve analysis to compare 3 versions of Partin Tables to predict final pathologic stage.
Urol Oncol. 2010; 30(4):396-401
Doi: 10.1016/j.urolonc.2010.07.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Augustin Herbert
- Co-Autor*innen der Med Uni Graz
- Pummer Karl
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- Abstract:
- Objective: To perform a decision curve analysis (DCA) to compare the Partin Tables 1997, 2001, and 2007 for their clinical applicability. Material and methods: Clinical and pathologic data of 687 consecutive patients treated with open radical prostatectomy for clinically localized prostate cancer between 2003 and 2008 at a single institution were used. DCA quantified the net benefit relating to specific threshold probabilities of extraprostatic extension (EPE), seminal vesicle involvement (SW), and lymph node involvement (LNI). Results: Overall, EPE, SVI, and LNI were recorded in 17.8, 6.0, and 1.2%, respectively. For EPE predictions, the DCA favored the 2007 version vs. 1997 for SVI vs. none of the versions for LNI. Conclusions: DCA indicate that for very low prevalence conditions such as LNI (1.2%), decision models are not useful. For low prevalence rates such as SVI, the use of different versions of the Partin Tables does not translate into meaningful net gains differences. Finally, for intermediate prevalence conditions such as EPE (18%), despite apparent performance differences, the net benefit differences were also marginal. In consequence, the current analysis could not confirm an important benefit from the use of the Partin Tables and it could not identify a clearly better version of any of the 3 available iterations. (C) 2012 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biopsy -
- Cohort Studies -
- Decision Support Techniques -
- Humans -
- Lymph Nodes - pathology
- Male -
- Middle Aged -
- Neoplasm Grading -
- Neoplasm Staging -
- Nomograms -
- Prostate - pathology
- Prostate-Specific Antigen - blood
- Prostatectomy -
- Prostatic Neoplasms - blood
- Reproducibility of Results -
- Seminal Vesicles - pathology
- Find related publications in this database (Keywords)
- Decision curve analysis
- Nomogram
- Partin Tables
- Prostate cancer
- Radical prostatectomy