Medizinische Universität Graz - Research portal
Selected Publication:
Fridrik, MA; Jäger, G; Baldinger, C; Krieger, O; Chott, A; Bettelheim, P.
First-line treatment of Waldenström's disease with cladribine. Arbeitsgemeinschaft Medikamentöse Tumortherapie.
Ann Hematol. 1997; 74(1):7-10
Doi: 10.1007%2Fs002770050247
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- Co-authors Med Uni Graz
- Jaeger Gerald
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- Abstract:
- PURPOSE: To assess the activity and side effects of cladribine (2-CdA) treatment in patients with advanced Waldenström's disease. PATIENTS AND METHODS: Ten symptomatic patients without prior therapy were included in a prospective multicenter trial. 2-CdA was administered daily at 0.12 mg/kg body weight in a 2-h i.v. infusion over 5 consecutive days: this was repeated every 28 days for four cycles. Patients achieving a remission received interferon alfa-2c (1F) 15 micrograms s.c. three times a week for 1 year. RESULTS: All 10 patients responded to 2-CdA (100%; 95% confidence interval, 68-100%), with one complete (CR) and eight partial responders (PR): one patient had only one 2-CdA cycle and showed a minor improvement (MR). Patients tolerated the treatment well. Despite considerable immunosuppression, an infection occurred in only two patients. After a median observation period of 57 weeks, three patients had shown progression, including one who died of lymphoma. CONCLUSION: 2-CdA induction and IF maintenance is a well-tolerated therapy for symptomatic untreated patients with advanced Waldenström's disease and offers excellent palliation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Agents - therapeutic use
- Cladribine - adverse effects
- Female - adverse effects
- Humans - adverse effects
- Interferon Type I, Recombinant - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Neutropenia - chemically induced
- Prospective Studies - chemically induced
- Remission Induction - chemically induced
- Waldenstrom Macroglobulinemia - drug therapy
- Find related publications in this database (Keywords)
- Waldenstroms Disease
- Low-Grade NHL
- 2-CDA
- Treatment