Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fellgiebel, A; Keller, I; Martus, P; Ropele, S; Yakushev, I; Böttcher, T; Fazekas, F; Rolfs, A.
Basilar artery diameter is a potential screening tool for fabry disease in young stroke patients.
Cerebrovasc Dis. 2011; 31(3): 294-299.
Doi: 10.1159/000322558
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Ropele Stefan
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- Abstract:
- Background: Fabry disease (FD) is a rare hereditary lysosomal storage disease that has been highlighted as a possible etiology of stroke at a young age. Enlarged basilar artery diameters (BADs) have been demonstrated in FD, and we hypothesize that they might be useful for the screening of FD in young stroke patients. The aim of this study was to compare BADs of young stroke patients without FD to those of FD patients and of healthy age-matched controls. Methods: BADs were measured using MR angiography in 3 age-and gender-matched groups: 25 FD patients (aged 36.5 +/- 11.0 years), 26 non-FD stroke patients and 20 healthy controls. Results: Compared to the non-FD stroke patients, FD patients had significantly enlarged BADs. FD patients could be significantly separated from stroke patients by BADs (area under the curve = 0.89, 95% confidence interval 0.81-0.98). Eighty-six percent of all subjects could be correctly classified by BADs (sensitivity 84%, specificity 88.5%). Conclusions: Enlarged BADs were able to detect FD within a cohort of FD, stroke patients and healthy controls. BAD measurement could be an easily obtainable and sensitive screening tool for FD in young stroke patients. Copyright (C) 2010 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Analysis of Variance -
- Basilar Artery - pathology
- Case-Control Studies -
- Cerebral Angiography -
- Chi-Square Distribution -
- Dilatation, Pathologic -
- Fabry Disease - complications
- Female -
- Female -
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Mass Screening - methods
- Middle Aged -
- Predictive Value of Tests -
- Retrospective Studies -
- Risk Assessment -
- Risk Factors -
- Sensitivity and Specificity -
- Stroke - etiology
- Find related publications in this database (Keywords)
- Basilar artery
- Fabry disease
- Young stroke patients