Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moser, G; Orendi, K; Gauster, M; Siwetz, M; Helige, C; Huppertz, B.
The art of identification of extravillous trophoblast.
Placenta. 2011; 32(2): 197-199.
Doi: 10.1016/j.placenta.2010.11.008
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Moser Gerit
- Co-Autor*innen der Med Uni Graz
- Aubell Kristina
- Gauster Martin
- Helige Christine
- Huppertz Berthold
- Siwetz Monika
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- Abstract:
- Immunohistochemical staining with specific markers for the respective cell type facilitates tracking and identification of cells such as extravillous trophoblast in the uterine wall. Cytokeratin has been recommended as a marker for all kinds of trophoblasts and is commonly used as a marker to identify interstitial as well as endovascular trophoblast. With immunohistochemical double staining of specimens of first trimester placental bed we show that staining with anti-cytokeratin alone is not sufficient to track all routes of trophoblast invasion. Endovascular trophoblasts can be easily mixed up with endoglandular trophoblasts. Thus, additional application of specific markers for extravillous trophoblast such as anti-HLA-G is strongly recommended, ideally in combination with other markers in immunohistochemical or immunofluorescence double staining.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Markers - analysis
- Female -
- HLA Antigens - immunology
- HLA-G Antigens -
- Histocompatibility Antigens Class I - immunology
- Humans -
- Immunohistochemistry - methods
- Keratins - immunology
- Placenta - immunology
- Pregnancy - immunology
- Pregnancy Trimester, First -
- Staining and Labeling - methods
- Trophoblasts - immunology
- Find related publications in this database (Keywords)
- HLA-G
- Cytokeratin
- Endoglandular trophoblast
- Endovascular trophoblast
- Double staining