Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kincses, ZT; Ropele, S; Jenkinson, M; Khalil, M; Petrovic, K; Loitfelder, M; Langkammer, C; Aspeck, E; Wallner-Blazek, M; Fuchs, S; Jehna, M; Schmidt, R; Vécsei, L; Fazekas, F; Enzinger, C.
Lesion probability mapping to explain clinical deficits and cognitive performance in multiple sclerosis.
Mult Scler. 2011; 17(6): 681-689.
Doi: 10.1177/1352458510391342
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Enzinger Christian
- Co-Autor*innen der Med Uni Graz
- Aspeck Engelbert
- Fazekas Franz
- Fuchs Siegrid
- Jehna Margit
- Khalil Michael
- Koini Marisa
- Langkammer Christian
- Petrovic Katja-Elisabeth
- Ropele Stefan
- Schmidt Reinhold
- Wallner-Blazek Mirja
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- Abstract:
- Background: Lesion dissemination in time and space represents a key feature and diagnostic marker of multiple sclerosis (MS). The correlation between magnetic resonance imaging (MRI) lesion load and disability is only modest, however. Strategic lesion location might at least partially account for this 'clinico-radiologic parado'x. Objectives: Here we used a non-parametric permutation-based approach to map lesion location probability based on MS lesions identified on T2-weighted MRI. We studied 121 patients with clinically isolated syndrome, relapsing-remitting or secondary progressive MS and correlated these maps to assessments of neurologic and cognitive functions. Results: The Expanded Disability Status Scale correlated with bilateral periventricular lesion location (LL), and sensory and coordination functional system deficits correlated with lesion accumulation in distinct anatomically plausible regions, i.e. thalamus and middle cerebellar peduncule. Regarding cognitive performance, decreased verbal fluency correlated with left parietal LL comprising the putative superior longitudinal fascicle. Delayed spatial recall correlated with _amygdalar, _left frontal and parietal LL. Delayed selective reminding correlated with bilateral frontal and temporal LL. However, only part of the spectrum of cognitive and neurological problems encountered in our cohort could be explained by specific lesion location. Conclusions: Lesion probability mapping supports the association of specific lesion locations with symptom development in MS, but only to limited extent.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Attention -
- Attention -
- Brain - pathology
- Brain Mapping - methods
- Cognition -
- Demyelinating Diseases - diagnosis Demyelinating Diseases - pathology Demyelinating Diseases - psychology
- Diffusion Magnetic Resonance Imaging -
- Disability Evaluation -
- Executive Function -
- Female -
- Humans -
- Male -
- Memory -
- Middle Aged -
- Multiple Sclerosis, Chronic Progressive - diagnosis Multiple Sclerosis, Chronic Progressive - pathology Multiple Sclerosis, Chronic Progressive - psychology
- Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - pathology Multiple Sclerosis, Relapsing-Remitting - psychology
- Neuropsychological Tests -
- Predictive Value of Tests -
- Severity of Illness Index -
- Time Factors -
- Verbal Behavior -
- Find related publications in this database (Keywords)
- cognition
- disability
- lesion symptom mapping
- MRI
- multiple sclerosis
- verbal fluency