Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aigelsreiter, A; Gerlza, T; Deutsch, AJ; Leitner, E; Beham-Schmid, C; Beham, A; Popper, H; Borel, N; Pospischil, A; Raderer, M; Kessler, HH; Neumeister, P.
Chlamydia psittaci Infection in nongastrointestinal extranodal MALT lymphomas and their precursor lesions.
Am J Clin Pathol. 2011; 135(1): 70-75.
Doi: 10.1309/AJCPXMDRT1SY6KIV
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- Führende Autor*innen der Med Uni Graz
- Aigelsreiter Ariane
- Neumeister Peter
- Co-Autor*innen der Med Uni Graz
- Beham Alfred
- Beham-Schmid Christine
- Deutsch Alexander
- Kessler Harald
- Leitner-Meyer Eva
- Popper Helmuth
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- Abstract:
- Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis DNA in 47 nongastrointestinal and 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, and 27 autoimmune precursor lesions by polymerase chain reaction amplification and direct sequencing. In 47 nongastrointestinal MALT lymphomas, 13 (28%) were positive for C psittaci DNA compared with 4 (11%) of 37 nonmalignant control samples (P = .09). C psittaci was detected at variable frequencies in MALT lymphomas of different sites: lung, 100% (5/5; P < .01); thyroid gland, 30% (3/10; P > .05); salivary gland, 13% (2/15; P > .05); ocular adnexa, 15% (2/13); and skin, 25% (1/4). Of 27 autoimmune precursor lesions (11 Hashimoto thyroiditis and 16 Sjögren syndrome), 11 (41%) contained C psittaci DNA. Only 1 (7%) of 14 gastrointestinal MALT lymphomas was positive for C psittaci. All specimens were negative for C trachomatis and C pneumoniae. Besides ocular adnexal lymphomas, C psittaci infection is associated with nongastrointestinal MALT lymphomas and autoimmune precursor lesions, suggesting possible involvement of C psittaci-induced antigenic-driven MALT lymphomagenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Bacterial - analysis
- Chlamydia trachomatis - genetics Chlamydia trachomatis - immunology Chlamydia trachomatis - isolation and purification
- Chlamydophila pneumoniae - genetics Chlamydophila pneumoniae - immunology Chlamydophila pneumoniae - isolation and purification
- Chlamydophila psittaci - genetics Chlamydophila psittaci - immunology Chlamydophila psittaci - isolation and purification
- DNA, Bacterial - analysis
- Eye Neoplasms - microbiology Eye Neoplasms - pathology
- Hashimoto Disease - blood Hashimoto Disease - microbiology Hashimoto Disease - pathology
- Humans -
- Immunoenzyme Techniques -
- Lymphoma, B-Cell, Marginal Zone - blood Lymphoma, B-Cell, Marginal Zone - microbiology Lymphoma, B-Cell, Marginal Zone - pathology
- Psittacosis - blood Psittacosis - diagnosis Psittacosis - microbiology
- Sequence Analysis, DNA -
- Sjogren's Syndrome - blood Sjogren's Syndrome - microbiology Sjogren's Syndrome - pathology
- Find related publications in this database (Keywords)
- MALT lymphoma
- Chlamydia psittaci
- Infection