Medizinische Universität Graz - Research portal
Selected Publication:
Halbmayer, WM; Haushofer, A; Schön, R; Radek, J; Fischer, M.
Comparison of a new automated kinetically determined fibrinogen assay with the 3 most used fibrinogen assays (functional, derived and nephelometric) in Austrian laboratories in several clinical populations and healthy controls.
Haemostasis. 1995; 25(3):114-123
Doi: 10.1159/000217150
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Haushofer Alexander
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- Abstract:
- A new automated kinetically determined fibrinogen assay was measured in plasmas of healthy subjects and three clinical cohorts (acute-phase reaction, liver cirrhosis and fibrinolytic therapy) that were expected to show normal, high and low levels of fibrinogen. The results were compared with the results of fibrinogen measurement using the derived method, the method according to Clauss and an immunological-nephelometric method. Altogether, the best correlation was achieved between the kinetic and the derived method. However, results from the derived method were generally higher than values obtained through the kinetic method. This was particularly true for high concentration levels above 400 mg/dl (patients with acute phase reaction) as well as for plasmas containing fibrin(ogen) degradation products and low concentrations of fibrinogen (below 150 mg/dl). Fibrinogen determinations in several commercial plasma pools with declared fibrinogen levels show remarkable heterogeneity when different methods were applied. To improve the discernment of fibrinogen determinations we suggest adjustment of standard preparations to international reference materials and the specification of the method used. Furthermore the attending physician is asked to cast a critical eye on fibrinogen values with regard to the used method of determination.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute-Phase Reaction - blood Acute-Phase Reaction - etiology
- Adult -
- Aged -
- Aged -
- Case-Control Studies -
- Cohort Studies -
- Coronary Artery Bypass -
- Coronary Disease - blood Coronary Disease - surgery
- Female -
- Fibrinogen - analysis
- Humans -
- Kinetics -
- Liver Cirrhosis - blood
- Male -
- Middle Aged -
- Nephelometry and Turbidimetry -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- FIBRINOGEN
- FIBRINOGEN DETERMINATION
- FIBRINOGEN CLAUSS
- FIBRINOGEN DERIVED
- FIBRINOGEN IMMUNOLOGICAL
- FIBRINOGEN KINETIC
- ACUTE-PHASE REACTION
- LIVER CIRRHOSIS
- THROMBOLYTIC THERAPY