Medizinische Universität Graz - Research portal
Selected Publication:
Dittel, M; Haushofer, A; Spiel, R; Halbmayer, WM; Prachar, H; Fischer, M; Mlczoch, J.
Changes in antithrombin III, prothrombin fragment 1 + 2 and thrombin-antithrombin III complex following implantation of a coronary Palmaz-Schatz stent.
Z Kardiol. 1995; 84(1):22-29
Web of Science
PubMed
- Co-authors Med Uni Graz
- Haushofer Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- To detect changes in the clotting parameters antithrombin III (AT III), prothrombin-fragment 1 + 2 (F 1 + 2) and thrombin-antithrombin-III-complex (TAT) after implantation of Palmaz Schatz stents, coagulation was monitored at standardized time points in 35 patients for 10 days. All patients were anticoagulated using a combination of heparin, phenprocoumon, and acetyl salicylic acid. Heparin therapy was guided by APTT levels (normal range 25-35 s), which were still within the therapeutic range (median 49.6 s (25%/75% percentiles 41.6/54.4) on day 10. Simultaneous oral anticoagulation was found to be effective on day 8 on average (INR median 2.24 (1.93/2.50)). The AT III activity dropped significantly (p < 0.0001) after a heparin loading dose of 15,000 IU during stenting. As the heparin dose was reduced on the following days, AT III levels increased significantly (p < 0.0001) during the observation time. There was a highly significant (p < 0.001) negative correlation between AT III and heparin levels. On days 4 and 5 F 1 + 2 values were significantly (p < 0.001 and p < 0.05) higher than on the day of stenting (median 1.07 (0.90/1.31) 1.13 nmol/l and 1.06 (0.85/1.23) nmol/l vs. 0.97 (0.69/1.15) nmol/l) and dropped during anticoagulation. F 1 + 2 levels showed a significant negative correlation (p < 0.0005) with APTT values. TAT values showed no significant changes during the observation period.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Angina Pectoris - blood Angina Pectoris - therapy
- Anticoagulants - administration and dosage
- Antithrombin III - analysis
- Aspirin - administration and dosage
- Blood Coagulation Factors - analysis
- Female -
- Heparin - administration and dosage
- Humans -
- Male -
- Middle Aged -
- Peptide Fragments - analysis
- Peptide Hydrolases - analysis
- Phenprocoumon - administration and dosage
- Prothrombin - analysis
- Stents -
- Thrombosis - prevention and control
- Find related publications in this database (Keywords)
- PALMAZ SCHATZ STENT
- ANTITHROMBIN III
- PROTHROMBIN FRAGMENT 1+2
- THROMBIN ANTITHROMBIN-III COMPLEX
- STENT THROMBOSIS
- ANTICOAGULATION