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Selected Publication:
Halbmayer, WM; Haushofer, A; Radek, J; Schön, R; Deutsch, M; Fischer, M.
Prevalence of factor XII (Hageman factor) deficiency among 426 patients with coronary heart disease awaiting cardiac surgery.
Coron Artery Dis. 1994; 5(5):451-454
Doi: 10.1097/00019501-199405000-00012
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- Co-authors Med Uni Graz
- Haushofer Alexander
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- Abstract:
- Background: Several case reports of myocardial infarction in patients with factor XII deficiency have been published. In the present study we investigated the prevalence of this condition. Methods: Factor XII activity (one-stage clotting assay), fibrinogen (derived method), and lipoprotein (a) (enzyme-linked immunosorbent assay) were measured in the plasma of 426 consecutive patients with coronary heart disease awaiting cardiac surgery. Results: Among the 426 patients, 44 (10.3%) were found to be moderately deficient in factor XII (factor XII activity 17-50%, antigen 15-57%). The prevalence of factor XII deficiency was significantly higher (P < 0.0001) among patients with coronary heart disease than among 300 healthy blood donors (2.3%). Among coronary heart disease patients with this deficiency, elevated levels of fibrinogen, lipoprotein (a), and blood pressure were no more prevalent than in those without the deficiency; nor were cigarette smoking or a positive family history of thromboembolism more prevalent. Conclusions: Coronary heart disease patients showed a 10% prevalence of factor XII deficiency. However, the pattern of atherosclerotic risk factors did not differ between patients with or without the deficiency.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Coagulation Tests -
- Coronary Artery Bypass -
- Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - surgery
- Factor XII Deficiency - epidemiology
- Female -
- Humans -
- Male -
- Middle Aged -
- Prevalence -
- Risk Factors -
- Find related publications in this database (Keywords)
- FACTOR XII
- FACTOR XII DEFICIENCY
- FIBRINOGEN
- LIPOPROTEIN (A)
- CORONARY HEART DISEASE
- MYOCARDIAL INFARCTION