Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aigner, RM; Fueger, GF.
First experiences with technetium-99m furifosmin as tumour-seeking agent in breast cancer and recurrent ovarian cancer.
Eur J Nucl Med. 1997; 24(9):1167-1170
Doi: 10.1007/BF01254251
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Aigner Reingard
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- Abstract:
- Recent in vitro studies suggest that technetium-99m furifosmin may have tumour-seeking properties. We analysed the diagnostic value of 99mTc-furifosmin scintigraphy in nine patients with documented carcinoma of the breast and in eight patients with continued recurrent ovarian cancer. In the breast, 99mTc-furifosmin failed to visualize the primary malignant tumour and the associated malignant lymph nodes in all patients. In contrast, multiple sites of increased tracer uptake were demonstrated in one patient with acute benign inflammatory breast disease. In four of eight patients with recurrent ovarian cancer, 99mTc-furifosmin scintigraphy demonstrated early (5 min p.i.) localized increased uptake corresponding to adhesions to the bowel as diagnosed by computed tomography, but failed to reveal further abnormalities in all patients. The present study demonstrates that furifosmin is of no value in the imaging of breast cancer and recurrent ovarian cancer. These results do not continue the pattern observed in cell culture studies and are quite in contrast to the findings of mammoscintigraphy using 99mTc-methoxyisobutylisonitrile and 99mTc-tetrofosmin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Breast Neoplasms - pathology Breast Neoplasms - radionuclide imaging
- Female -
- Furans - diagnostic use
- Humans -
- Lymph Nodes - radionuclide imaging
- Lymphatic Metastasis -
- Middle Aged -
- Neoplasm Recurrence, Local - radionuclide imaging
- Organotechnetium Compounds - diagnostic use
- Ovarian Neoplasms - pathology Ovarian Neoplasms - radionuclide imaging
- Radiopharmaceuticals - diagnostic use
- Find related publications in this database (Keywords)
- Tc-99m Furifosmin
- Radionuclide Imaging
- Breast Cancer
- Ovarian Cancer