Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haschke-Becher, E; Kirchheiner, J; Trummer, O; Grunbacher, G; Kainz, A; Boehm, BO; Marz, W; Renner, W.
Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.
PHARMACOGENOMICS. 2010; 11(10): 1359-1365.
Doi: 10.2217/pgs.10.96
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Grünbacher Gerda
- März Winfried
- Trummer Olivia
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- Abstract:
- Aims: As data on the cardiovascular risk associated with CYP2C8 and CYP2C9 polymorphisms is controversial, we performed a cross-sectional analysis of subjects enrolled in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Materials & methods: CYP2C8 and CYP2C9 genetic polymorphisms were determined with real-time PCR in 2827 patients. Based on angiography, 1052 of these patients had coronary artery disease (CAD) and 615 did not; 1160 patients had signs or a history of myocardial infarction (MI) in addition to CAD. The association of genotypes with CAD and MI was determined by logistic regression analysis, adjusted for age, sex, dyslipidemia, hypertension, diabetes mellitus and smoking status. Results: Frequencies of CYP2C8 and 2C9 variants were neither significantly different between CAD and control patients, nor between MI and control patients. Men carrying the CYP2C9*3 allele had an increased risk of MI (odds ratio [OR]: 1.67; 95% CI: 1.06-2.63; p = 0.03) and women carrying the CYP2C9*3 allele had a decreased risk of CAD (OR: 0.65; 95% CI: 0.42-0.9; p = 0.05). Conclusion: Overall, LURIC data confirmed that there is no major cardiovascular risk associated with CYP2C8 and CYP2C9 variants in a cardiovascular risk population of patients having undergone coronary angiography.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aryl Hydrocarbon Hydroxylases - genetics
- Cohort Studies -
- Coronary Artery Disease - enzymology
- Cross-Sectional Studies -
- Female -
- Genetic Variation -
- Humans -
- Male -
- Middle Aged -
- Myocardial Infarction - enzymology
- Polymorphism, Genetic - genetics
- Risk Factors -
- Sex Factors -
- Find related publications in this database (Keywords)
- coronary artery disease
- CYP2C8
- CYP2C9
- myocardial infarction observational study
- polymorphism