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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tallon, B; Cerroni, L.
Where pigmented pilomatricoma and melanocytic matricoma collide.
AMER J DERMATOPATHOL. 2010; 32(8): 769-773.
Doi: 10.1097/DAD.0b013e3181d88d15
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- Leading authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Pilomatricoma and matricoma are 2 benign epithelial tumours derived from the hair matrix. Although containing the same constituent cells, the silhouette differs, with matricoma comprised of a predominantly solid basaloid proliferation with only focal areas of shadow cell formation. The recently described melanocytic matricoma appears to be a similar tumor with numerous interspersed melanocytes. We studied retrospectively 28 pilomatricomas and 2 pilomatrical carcinomas to check for the presence of melanocytes using immunohistochemical staining to S-100 and Melan-A. Three cases of pilomatricoma with prominent melanocytic hyperplasia were detected, confirming this as a rare (11%) occurrence. Both cases of pilomatrical carcinoma were negative. Comparison of these tumors with a further case of melanocytic matricoma led to a critical analysis of the relationship of pilomatricoma, matricoma, and melanocytic matricoma. Although further comparison is required, we suggest that melanocytic matricoma may be simply a pigmented melanocytic variant of matricoma, in the same way as we accept pigmented pilomatricoma as a variant of pilomatricoma. In this report we provide features that may be used to discriminate matricoma and pilomatricoma and their pigmented variants.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Aged -
- Antigens, Neoplasm - analysis
- Cell Proliferation -
- Child -
- Diagnosis, Differential -
- Female -
- Hair Diseases - metabolism
- Humans -
- Hyperplasia -
- Immunohistochemistry -
- Male -
- Melanocytes - chemistry
- Middle Aged -
- Neoplasm Proteins - analysis
- Pilomatrixoma - chemistry
- Predictive Value of Tests -
- Retrospective Studies -
- S100 Proteins - analysis
- Skin Neoplasms - chemistry
- Skin Pigmentation -
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- pilomatricoma
- pigmented matricoma
- matricoma