Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kuhnt, K; Flotho, S; Benjamin, S; Boerchers, T; Schubert, R; Jahreis, G; Spener, F.
Gene expression after dietary intervention with trans fatty acids (trans-11/trans-12 18:1) in humans
EUR J LIPID SCI TECHNOL. 2009; 111(5): 442-450.
Doi: 10.1002/ejlt.200800217
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- Gene-by-diet interactions play an important role in the prevention of several diseases. Conjugated linoleic acids (CLA) are ligands of gene regulators [e.g. peroxisome proliferator-activated receptors (PPAR)] and have anti-inflammatory properties. The aim of the study was to investigate the changes in gene expression in monocytes during the intervention with two trans fatty acids (trans-11 18:1 and trans-12 18:1) and endogenous CLA from trans-11 18:1 as precursor in humans. Monocytes were isolated at baseline and after a 6-week intervention period. The female and male test groups received Sigma 6.0 g trans-11 and trans-12 18:1/day (1 : 1). The control group received control oil. The expression of candidate genes was determined by quantitative RTPCR. Gender- and treatment-related gene expression was found. Due to trans fatty acid intake in both gender subgroups, the relative PPAR gamma expression was up-regulated. In the female test group, the expression of FAT, SCD, COX2 and BCL2 were induced, while in the male test group E-FABP CYP, GLUT4 and PBE were induced. In the male test group compared to controls, a clear increase in gene expression of PPAR gamma and GLUT4 was shown. The results reveal a gender- and treatment-related gene expression. There is no clear indication as to what extent the supplemented trans fatty acids and the synthesized cis-9,trans-11 CLA were involved.
- Find related publications in this database (Keywords)
- Conjugated linoleic acids
- Gene expression
- Nutrigenomics
- Peroxisome proliferator-activated receptors
- Trans fatty acids