Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wolfrum, C; Spener, F.
Chlorophyll-derived fatty acids regulate expression of lipid metabolizing enzymes in liver - a nutritional opportunity
OCL-OL CORPS GRAS LIPIDES. OCL-OLEAGINEUX CORPS GRAS LIPIDES; 8: 39-44.
Doi: 10.1051/ocl.2001.0039
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- Führende Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- Nutritional values of fatty acid classes are normally discussed on the basis of their saturated, monounsaturated and polyunsaturated structures with implicit understanding that they are straight-chain. Here we focus on chlorophyll-derived phytanic and pristanic acids that are minor isoprenoid branched-chain lipid constituents in food, but of unknown nutritional value. After describing the enzyme machinery that degrades these nutrient fatty acids in the peroxisome, we show by the criteria of a mouse model and of a human cell culture model that they induce with high potency expression of enzymes responsible for P-oxidation of straight-chain fatty acids in the peroxisome. We summarize present mechanistic knowledge on fatty acid signaling to the nucleus, which involves protein/protein contacts between peroxisome proliferator activated receptor (PPAR) and fairy acid binding protein (FABP). In this signaling event the branched-chain fatty acids are the most effective ones. Finally on the basis of this nutrient-gene interaction we discuss nutritional opportunities and therapeutic aspects of the chlorophyll-derived fatty acids.
- Find related publications in this database (Keywords)
- phytanic acid
- pristanic acid
- gene regulation
- peroxisome proliferator activated receptor(PPAR)
- fatty acid binding protein (FABP)
- beta-oxidation