Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Yevdokimov, YM; Salyanov, VI; Mchedlischvili, BV; Bykov, VA; Belyaev, AV; Saunin, SA; Spener, F; Palumbo, M.
Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular structures
NUCLEOS NUCLEOT NUCLEIC ACIDS. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS; 19: 1355-1364.
Doi: 10.1080/15257770008033057
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units.
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