Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schuch, R; Winter, E; Bruck, FM; Brummel, M; Spener, F.
beta-Ketoacyl-acyl carrier protein synthases in the regulation of fatty acid synthase activity in higher plants - An overview
FETT-LIPID. 1997; 99(8): 278-281.
Doi: 10.1002/lipi.19970990804
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- The role of beta-ketoacyl-ACP synthases (condensing enzymes, KAS) in the regulation of the biosynthesis of medium-chain fatty acids in Cuphea lanceolata seed (86.5% decanoic acid in oil) was investigated. KAS III catalyzes the first condensing step of fatty acid synthase (FAS) reaction between acetyl-CoA and malonyl-ACP. This condensing reaction was highly sensitive to inhibition by decanoyl-ACP, as determined using FAS preparations from C. lanceolata seeds. These data provide strong evidences that KAS III is a target for feedback regulation of fatty acid biosynthesis. Studies on the elongation of octanoyl-and hexadecanoyl-ACP by KAS I and KAS II, respectively, showed that the accumulation of beta-ketoacyl-ACP, the direct product of condensing reaction, results in decarboxylation of malonyl-ACP to acetyl-ACP. The data demonstrate that condensing enzymes can modulate the levels of malonyl-ACP inside the plastids during the fatty acid biosynthesis.