Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stolle, K; Schnoor, M; Fuellen, G; Spitzer, M; Engel, T; Spener, F; Cullen, P; Lorkowski, S.
Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene.
Gene. 2005; 351(6-7):119-130
Doi: 10.1016/j.gene.2005.03.012
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- SMAP-5 is a member of the five-pass transmembrane protein family localizing in the Golgi apparatus and the endoplasmic reticulum. These proteins have been implicated in intracellular trafficking, in secretion and in vesicular transport. Phylogenetic analyses revealed that SMAP-5 is a member of a small Rab GTPase interacting factor protein family. The human SMAP-5 gene spans about 12.5 kb and comprises 6 exons on chromosomal locus 5q32. The proximal 5'-flanking region of the gene lacks a TATA box and is highly GC rich. Consistent with this, the SMAP-5 gene is expressed in all tissues. The highest level of expression was found in coronary smooth muscle cells, in which expression of the SMAP-5 gene was induced by transforming growth factor beta1, thus indicating that this protein may play an important role in inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Alternative Splicing -
- Base Sequence -
- Cells, Cultured -
- Chromosomes, Human, Pair 5 - genetics
- Cloning, Molecular -
- Coronary Vessels - cytology Coronary Vessels - drug effects Coronary Vessels - metabolism
- DNA, Complementary - chemistry DNA, Complementary - genetics
- Endoplasmic Reticulum - metabolism
- Exons -
- Female -
- Gene Expression - drug effects
- Gene Expression Profiling -
- Genes - genetics
- Golgi Apparatus - metabolism
- Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism
- Hela Cells -
- Humans -
- Introns -
- Male -
- Membrane Proteins - genetics Membrane Proteins - metabolism
- Molecular Sequence Data -
- Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism
- Phylogeny -
- Promoter Regions, Genetic - genetics
- Protein Sorting Signals - genetics
- RNA, Messenger - genetics RNA, Messenger - metabolism
- Regulatory Sequences, Nucleic Acid - genetics
- Reverse Transcriptase Polymerase Chain Reaction -
- Sequence Analysis, DNA -
- Transfection -
- Transforming Growth Factor beta - pharmacology
- Transforming Growth Factor beta1 -
- Up-Regulation - drug effects Up-Regulation - genetics
- Vesicular Transport Proteins -
- Find related publications in this database (Keywords)
- SB140
- FinGER5
- Yip1
- transforming growth factor beta 1