Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lachmann, RA; Werchan, S; Schachtrup, C; Haitsma, JJ; Spener, F; Lachmann, B.
Liver-type fatty acid binding protein in serum and broncho-alveolar lavage in a model of acute respiratory failure because of surfactant depletion--a possible marker for lung damage?
Clin Physiol Funct Imaging. 2006; 26(6):371-375
Doi: 10.1111/j.1475-097X.2006.00703.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- INTRODUCTION: Liver-type fatty acid binding proteins (L-FABP) have been shown to be present in alveolar macrophages and type II pneumocytes of the lung. This study determined levels of L-FABP in serum and broncho-alveolar lavage (BAL) during experimental acute respiratory failure (ARF) to evaluate whether this molecule can serve as a marker for lung damage. METHODS: Male Sprague-Dawley rats (n = 24) were ventilated and either lung lavaged or lavaged and treated with surfactant, and compared to ventilated, non-lavaged controls. Blood samples were drawn every hour for 4 h to measure L-FABP concentrations in serum. At the end of the experiment a BAL was performed to determine L-FABP levels in BAL fluid. L-FABP was measured with a sandwich enzyme-linked immunosorbent assays. RESULTS: Serum L-FABP concentrations rose significantly during the first 2 h of ventilation in all groups compared with baseline values. After 2 h L-FABP levels were significantly higher in lavaged animals compared with the ventilated controls and to animals treated with surfactant. After 4 h of ventilation, L-FABP in BAL was significantly higher in lavaged, non-surfactant treated animals compared with the ventilated controls. CONCLUSION: In the early phase of experimental ARF serum L-FABP levels correlate well with the degree of lung injury.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Alanine Transaminase - blood Alanine Transaminase - drug effects
- Animals -
- Aspartate Aminotransferases - blood Aspartate Aminotransferases - drug effects
- Biological Markers - blood
- Blood Gas Analysis -
- Bronchoalveolar Lavage -
- Carbon Dioxide - analysis
- Disease Models, Animal -
- Enzyme-Linked Immunosorbent Assay -
- Fatty Acid-Binding Proteins - blood Fatty Acid-Binding Proteins - drug effects
- Lung Compliance - drug effects
- Male -
- Oxygen - analysis
- Pulmonary Surfactants - pharmacology
- Random Allocation -
- Rats -
- Rats, Sprague-Dawley -
- Respiration, Artificial -
- Respiratory Insufficiency - blood Respiratory Insufficiency - physiopathology
- Time Factors -
- Find related publications in this database (Keywords)
- alveolar macrophages
- mechanical ventilation
- rat
- surfactant
- type II pneumocytes