Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nourani, MR; Owada, Y; Kitanaka, N; Sakagami, H; Hoshi, H; Iwasa, H; Spener, F; Kondo, H.
Occurrence of immunoreactivity for adipocyte-type fatty acid binding protein in degenerating granulosa cells in atretic antral follicles of mouse ovary.
J Mol Histol. 2005; 36(8-9):491-497
Doi: 10.1007/s10735-006-9024-y
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- The localization of adipocyte-type fatty acid binding protein (A-FABP) in the mature mouse ovary was examined by immuno-light and electron microscopy. Solitary round cells showing the distinct immunoreactivity for A-FABP were detected in 1-6 antral follicles. In sets of two consecutive sections in a mirror alignment on slide glasses which were treated for immunoreactivity for A-FABP and TUNEL reaction separately, cells immunoreactive for A-FABP appeared in the same antral follicles as containing cells exhibiting TUNEL-reaction. In immunoelectron microscopy, A-FABP-immunopositive cells were found to contain highly electron-dense nuclei of round, irregular or crescent shapes together with cytoplasmic remnants without any features of macrophages or cells of extrinsic origin. Therefore the cells were identified as apoptotic granulosa cells. The apoptotic cells immunoreactive for A-FABP were often seen to be enclosed/engulfed in adjacent cells exhibiting normal ultrastructures without containing numerous lysosomes. The present findings suggest that A-FABP is involved in the apoptosis of ovarian granulosa cells, probably through its interaction with peroxisome proliferator activated receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - metabolism
- Animals -
- Fatty Acid-Binding Proteins - immunology
- Female -
- Granulosa Cells - immunology Granulosa Cells - pathology Granulosa Cells - ultrastructure
- In Situ Nick-End Labeling -
- Mice -
- Mice, Inbred C57BL -
- Find related publications in this database (Keywords)
- A-FABP
- cell degeneration
- granulosa cell
- ovary
- mouse