Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Guthmann, F; Börchers, T; Wolfrum, C; Wustrack, T; Bartholomäus, S; Spener, F.
Plasma concentration of intestinal- and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates.
Mol Cell Biochem. 2002; 239(1-2):227-234
Doi: 10.1023/A:1020508420058
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- Both early diagnostic and prognostic assessment of the acute abdomen in preterm infants are hampered by the lack of a sensitive and specific parameter for intestinal injury. In this prospective clinical study we wanted to estimate the value of intestinal (I-) and liver (L-) fatty acid binding protein (FABP) in diagnosing necrotizing enterocolitis (NEC). Using highly sensitive and specific sandwich ELISAs which employ recombinant human I- and L-FABP as standard proteins (limit of detection 0.1 ng/ml plasma), the L-FABP concentration (median 7.6 ng/ml) was determined to be about 3 fold that of I-FABP (median 2.52 ng/ml) in plasma of healthy preterm infants. I- and L-FABP concentrations significantly increased with birth weight (1.6 and 5.0 ng/ ml per kg, respectively). At onset of symptoms, I-FABP concentration was significantly higher in infants who later developed severe NEC compared to healthy infants and those, whose illness remained confined to stage I or II. L-FABP was significantly elevated compared to the control group at onset of symptoms regardless of the further course of NEC. In conclusion, I-FABP appears to be a specific parameter for early detection of intestinal injury leading to severe NEC stage III. L-FABP, however, is a promising sensitive marker even for stage I of NEC.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Birth Weight -
- Carrier Proteins - blood Carrier Proteins - genetics
- Enterocolitis, Necrotizing - blood Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - pathology
- Enzyme-Linked Immunosorbent Assay -
- Fatty Acid-Binding Proteins -
- Gestational Age -
- Humans -
- Infant -
- Infant, Newborn -
- Infant, Premature - blood
- Neoplasm Proteins -
- Sensitivity and Specificity -
- Statistics as Topic -
- Tumor Suppressor Proteins -
- Find related publications in this database (Keywords)
- recombinant protein
- sandwich ELISA
- necrotizing enterocolitis
- neonates
- preterm infant
- fatty acid binding protein