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Selected Publication:
Bloms, P; Musshoff, U; Madeja, M; Müsch-Nittel, K; Kuhlmann, D; Spener, F; Speckmann, EJ.
Suppression of a ligand operated membrane current by the epileptogenic agent pentylenetetrazol in oocytes of Xenopus laevis after injection of rat brain RNA.
Neurosci Lett. 1992; 147(2):155-158
Doi: 10.1016/0304-3940(92)90583-S
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- Co-authors Med Uni Graz
- Spener Friedrich
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- Abstract:
- The effects of the epileptogenic substance pentylenetetrazol (PTZ) on ligand operated membrane channels were studied. For this purpose serotonin (5-HT) sensitive channels were expressed in RNA injected oocytes of Xenopus laevis. With simultaneous application of both substances, the response to 5-HT was reduced and eventually abolished by PTZ with increasing concentrations (5-100 mM). A reduction of the 5-HT response also appeared when PTZ was applied in various intervals (15 and 240 s) before 5-HT. It may be assumed that PTZ produces a component of its epileptogenic effect by acting on ligand operated membrane channels.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain Chemistry - physiology
- Cell Membrane - drug effects Cell Membrane - metabolism
- Ion Channels - drug effects
- Ligands -
- Oocytes - drug effects Oocytes - metabolism
- Pentylenetetrazole - pharmacology
- RNA - pharmacology
- Rats -
- Xenopus laevis -
- Find related publications in this database (Keywords)
- EPILEPSY
- PENTYLENETETRAZOL
- LIGAND OPERATED CHANNEL
- SEROTONIN
- XENOPUS OOCYTE
- RNA INJECTION