Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Bloms-Funke, P; Musshoff, U; Madeja, M; Spener, F; Speckmann, EJ.
Decrease and increase of responses to glutamate receptor agonists in RNA-injected Xenopus oocytes by the epileptogenic agent pentylenetetrazol: dependence on the agonist concentration.
Neurosci Lett. 1994; 181(1-2):161-164
Doi: 10.1016/0304-3940(94)90584-3
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- Co-Autor*innen der Med Uni Graz
- Spener Friedrich
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- Abstract:
- The effects of the epileptogenic agent pentylenetetrazol (PTZ) on current responses to glutamate (Glu) and to the Glu receptor agonist N-methyl-D-aspartate (NMDA), kainate (KA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and quisqualate (QA) were studied on RNA-injected Xenopus oocytes. PTZ antagonized the reactions to Glu as well as to NMDA, KA, AMPA and QA. With increasing concentration of AMPA, however, the depressive effect of PTZ turned to an augmentation. The complete change from a decreasing to an increasing effect of PTZ with elevated agonist concentration was unique for current responses by AMPA.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Epilepsy - chemically induced
- Excitatory Amino Acid Agonists - pharmacology
- Female -
- Injections -
- Oocytes - drug effects
- Osmolar Concentration -
- Pentylenetetrazole - pharmacology
- RNA - pharmacology
- Xenopus laevis -
- Find related publications in this database (Keywords)
- EPILEPTOGENESIS
- GLUTAMATE RECEPTOR
- AMPA
- PENTYLENETETRAZOL
- OOCYTE
- XENOPUS LAEVIS