Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lüers, C; Schmidt, A; Wachter, R; Fritzsche, F; Sutcliffe, A; Kleta, S; Zapf, A; Hagenah, G; Binder, L; Maisch, B; Pieske, B.
Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure.
Herz. 2010; 35(7):488-495
Doi: 10.1007/s00059-010-3377-4
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
- Schmidt Albrecht
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- Abstract:
- Purpose. NT-proBNP is an important prognostic predictor in patients with heart failure. However, it is unknown whether a change of NT-proBNP plasma levels in the early phase of decompensation might be of additional prognostic value in patients with acute decompensation of heart failure. Methods and results. NT-proBNP plasma levels of 116 patients with decompensated heart failure from ischemic/non-ischemic origin were measured at baseline and at 12,24 and 48 h after hospital admission. Baseline levels and changes of plasma levels within the first 48 h were correlated with 30-day mortality. In all patients, NT-proBNP 12 h after admission was highest and superior with respect to the prediction of 30-day mortality compared to plasma levels on admission. In total, 38 patients died within the first 30 days. In these patients absolute NT-proBNP plasma levels were significantly higher and the increase within 12 h after admission was more pronounced compared to survivors (p<0.001). NT-proBNP at 12 h after admission also had the highest predictive value for the 30-day mortality rate in patients with acute myocardial infarction. The increase of NT-proBNP plasma levels within 12 h after admission had the highest predictive value in patients suffering from decompensated heart failure. Conclusions. NT-proBNP is a powerful marker of 30-day mortality in patients with decompensated heart failure of ischemic and non-ischemic origin. Compared with single baseline measurements, serial measurements of NT-proBNP plasma levels within 12 h after hospital admission may be used to increase the predictive value of NT-proBNP with regard to the early identification of patients who are at high risk of mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biological Markers - blood
- Female -
- Female - epidemiology
- Heart Failure - blood Heart Failure - diagnosis Heart Failure - mortality
- Humans -
- Male -
- Natriuretic Peptide, Brain - blood
- Peptide Fragments - blood
- Prevalence -
- Reproducibility of Results -
- Risk Assessment - methods
- Risk Factors -
- Sensitivity and Specificity -
- Survival Analysis -
- Survival Rate -
- Find related publications in this database (Keywords)
- Heart failure
- Decompensated heart failure
- Natriuretic peptides
- NT-proBNP