Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Singleton, R; Etchart, N; Hou, S; Hyland, L.
Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses.
J Virol. 2003; 77(21):11303-11311
Doi: 10.1128/JVI.77.21.11303-11311.2003
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- Co-Autor*innen der Med Uni Graz
- Liechtenstein Nathalie
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- Abstract:
- Long-lasting protective antibody is not normally generated in children following primary respiratory syncytial virus (RSV) infection, frequently leading to reinfection. We used the BALB/c mouse model to examine the role of the nasal-associated lymphoid tissue and the bone marrow in the generation of RSV-specific long-lasting plasma cells, with a view to further understanding the mechanisms responsible for the poorly sustained RSV antibody levels following primary infection. We show here that substantial numbers of RSV-specific plasma cells were generated in the bone marrow following challenge, which were maintained thereafter. In contrast, in the nasal-associated lymphoid tissue, RSV-specific plasma cell numbers waned quickly both after primary infection and after challenge and were not maintained at a higher level after boosting. These data indicate that the inability to generate a robust local mucosal response in the nasal tissues may contribute substantially to the likelihood of subsequent reinfection and that the presence of serum anti-RSV antibody without local protection is not enough to protect against reinfection.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Viral - analysis Antibodies, Viral - blood
- Disease Models, Animal -
- Female -
- Immunoglobulin G - analysis Immunoglobulin G - blood
- Lung - virology
- Lymphoid Tissue - immunology
- Mice -
- Mice, Inbred BALB C -
- Nose - immunology
- Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - physiopathology Respiratory Syncytial Virus Infections - virology
- Respiratory Syncytial Virus, Human - immunology Respiratory Syncytial Virus, Human - pathogenicity