Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Le Bon, A; Etchart, N; Rossmann, C; Ashton, M; Hou, S; Gewert, D; Borrow, P; Tough, DF.
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon.
Nat Immunol. 2003; 4(10):1009-1015
Doi: 10.1038/ni978
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Liechtenstein Nathalie
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- CD8+ T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as cross-priming. To initiate cross-priming, APCs must both capture extracellular antigen and receive specific activation signals. We have investigated the nature of APC activation signals associated with virus infection that stimulate cross-priming. We show that infection with lymphocytic choriomeningitis virus induces cross-priming by a mechanism dependent on type I interferon (IFN-alpha/beta). Activation of cross-priming by IFN-alpha/beta was independent of CD4+ T cell help or interaction of CD40 and CD40 ligand, and involved direct stimulation of dendritic cells. These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigen Presentation - immunology
- Antigens, CD40 - immunology
- CD40 Ligand - immunology
- CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology
- Dendritic Cells - immunology
- Female -
- Interferon Type I - biosynthesis Interferon Type I - immunology
- Lymphocyte Activation - immunology
- Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology
- Lymphocytic choriomeningitis virus - immunology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Ovalbumin - immunology
- Specific Pathogen-Free Organisms -