Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Le Borgne, M; Etchart, N; Goubier, A; Lira, SA; Sirard, JC; van Rooijen, N; Caux, C; Aït-Yahia, S; Vicari, A; Kaiserlian, D; Dubois, B.
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.
Immunity. 2006; 24(2):191-201
Doi: 10.1016/j.immuni.2006.01.005
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- Co-Autor*innen der Med Uni Graz
- Liechtenstein Nathalie
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- Abstract:
- The nature of dendritic cell(s) (DC[s]) that conditions efficient in vivo priming of CD8+ CTL after immunization via epithelial tissues remains largely unknown. Here, we show that myeloid DCs rapidly recruited by adjuvants into the buccal mucosa or skin are essential for CD8+ T cell crosspriming. Recruitment of circulating DC precursors, including Gr1+ monocytes, precedes the sequential accumulation of CD11c+ MHC class II+ DCs in dermis and epithelium via a CCR6/CCL20-dependent mechanism. Remarkably, a defect in CCR6, local neutralization of CCL20, or depletion of monocytes prevents in vivo priming of CD8+ CTL against an innocuous protein antigen administered with adjuvant. In addition, transfer of CCR6-sufficient Gr1+ monocytes restores CD8+ T cell priming in CCR6( degrees / degrees ) mice via a direct Ag presentation mechanism. Thus, newly recruited DCs likely derived from circulating monocytes are responsible for efficient crosspriming of CD8+ CTL after mucosal or skin immunization.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic -
- Animals -
- CD8-Positive T-Lymphocytes - immunology
- Cell Movement -
- Chemokine CCL20 -
- Chemokines, CC - metabolism Chemokines, CC - physiology
- Clodronic Acid - pharmacology
- Dendritic Cells - immunology
- Dermis - metabolism
- Dinitrofluorobenzene - pharmacology
- Epithelium - immunology Epithelium - metabolism
- Female -
- H-2 Antigens - genetics H-2 Antigens - physiology
- Immunization -
- Langerhans Cells - physiology
- Macrophage Inflammatory Proteins - metabolism Macrophage Inflammatory Proteins - physiology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Mice, Transgenic -
- Mouth Mucosa - cytology Mouth Mucosa - immunology Mouth Mucosa - metabolism
- Nucleoproteins - immunology
- Receptors, CCR6 -
- Receptors, Chemokine - genetics Receptors, Chemokine - physiology
- Stem Cells - physiology