Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Etchart, N; Hennino, A; Friede, M; Dahel, K; Dupouy, M; Goujon-Henry, C; Nicolas, JF; Kaiserlian, D.
Safety and efficacy of transcutaneous vaccination using a patch with the live-attenuated measles vaccine in humans.
Vaccine. 2007; 25(39-40):6891-6899
Doi: 10.1016/j.vaccine.2007.07.014
Web of Science
PubMed
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- Liechtenstein Nathalie
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- Abstract:
- Transcutaneous immunisation (TCI) using a skin patch is a non-invasive vaccination route relevant to mass vaccination against infectious diseases. This phase I/II clinical study, documents that TCI of human adult volunteers with the live-attenuated measles vaccine ROUVAX((R)) is safe and poorly reactogenic. It promotes induction of measles-specific salivary IgA and a tendency to increased frequency of MV-specific IFNgamma-producing T cells. However, in contrast to the subcutaneous route, TCI failed to evoke neutralising MV-specific serum antibodies. Thus, alternative delivery methods and/or devices providing optimal uptake by skin DC should be considered for live-attenuated virus vaccines, such as the measles vaccine.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Adolescent -
- Adult -
- Animals -
- Cercopithecus aethiops -
- Humans -
- Immunoglobulin A, Secretory - analysis
- Interferon-gamma - biosynthesis
- Measles - prevention and control
- Measles Vaccine - administration and dosage Measles Vaccine - adverse effects Measles Vaccine - therapeutic use
- Measles virus - immunology
- T-Lymphocytes - immunology
- Treatment Outcome -
- Vaccination -
- Vaccines, Attenuated - administration and dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - therapeutic use
- Vero Cells -
- Find related publications in this database (Keywords)
- transcutaneous administration
- measles virus
- Vaccines
- IgA