Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bahadori, B; Uitz, E; Dehchamani, D; Pilger, E; Renner, W.
The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease
THROMB RES. 2010; 126(4): 350-352.
Doi: 10.1016/j.thromres.2010.07.007
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Pilger Ernst
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- Abstract:
- Conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in stabilization of the fibrin clot. Fibrinogen consists of three pairs of non-identical polypeptide chains, encoded by different genes (fibrinogen alpha [FGA], fibrinogen beta [FGB] and fibrinogen gamma [FGG]). A functional single nucleotide polymorphism (SNP) in the 3' untranslated region of the FGG gene (FGG 10034C>T, rs2066865) has been associated with deep venous thrombosis and myocardial infarction. Aim of the present study was to analyze the role of this polymorphism in peripheral arterial disease (PAD). The study was designed as case-control study including 891 patients with documented PAD and 777 control subjects. FGG genotypes were determined by exonuclease (TaqMan) assays. FGG genotype frequencies were not significantly different between PAD patients (CC: 57.3%, CT: 36.7%, TT: 5.8%) and control subjects (CC: 60.9%, CT: 33.5%, TT 5.6%; p=0.35). In a multivariate logistic regression analysis including age, sex, smoking, diabetes, arterial hypertension and hypercholesterolemia, the FGG 10034 T variant was not significantly associated with the presence of PAD (Odds ratio 1.07, 95% confidence interval 0.84 - 1.37; p = 0.60). The FGG 10034C>T polymorphism was furthermore not associated with age at onset of PAD. We conclude that the thrombophilic FGG 10034 T gene variant does not contribute to the genetic susceptibility to PAD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Case-Control Studies -
- Female -
- Fibrinogens, Abnormal - genetics
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Peripheral Vascular Diseases - etiology Peripheral Vascular Diseases - genetics
- Polymorphism, Single Nucleotide -
- Risk Factors -
- Find related publications in this database (Keywords)
- Fibrinogen gamma
- Polymorphism
- Genetics
- Peripheral arterial disease