Medizinische Universität Graz - Research portal
Selected Publication:
Tripathi, O; Schreibmayer, W; Tritthart, HA.
Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study.
Br J Pharmacol. 1993; 108(4):865-869
Doi: 10.1111/j.1476-5381.1993.tb13479.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schreibmayer Wolfgang
- Tritthart Helmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- 1. Fendiline, a diphenylalkylamine type of antianginal drug, was examined for its effects on L-type calcium channels in guinea-pig ventricular myocytes by the whole-cell patch-clamp technique. 2. Fendiline (0.3-100 microM) applied extracellularly inhibited the calcium channel current (ICa) in a concentration- and time-dependent manner. The IC50 of fendiline was 17.0 +/- 2.43 microM and the Hill slope was 1.39 +/- 0.23. 3. Inhibition of ICa by fendiline appeared with an onset of less than 3 s. 4. Fendiline inhibited ICa at all the membrane potentials tested and shifted the current-voltage curve upwards. The overall calcium channel conductance (gCa) of the cell was reduced and conductance-voltage curve was shifted to the left in the presence of fendiline. 5. Isoprenaline (0.5-1 microM), a beta-adrenoceptor agonist, partially reversed the inhibitory effect of fendiline on ICa. 6. It is suggested that fendiline applied extracellularly blocks L-type calcium channels and reduces calcium channel conductance of the cell. The calcium channels thus inhibited are, nevertheless, still available for beta-adrenoceptor stimulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium Channel Blockers - pharmacology
- Choline - pharmacology
- Culture Media - pharmacology
- Electrophysiology - pharmacology
- Fendiline - pharmacology
- Guinea Pigs - pharmacology
- Heart - drug effects
- Isoproterenol - pharmacology
- Membrane Potentials - drug effects
- Myocardium - cytology
- Tetrodotoxin - pharmacology
- Find related publications in this database (Keywords)
- Fendiline
- Diphenylalkylamine
- Isoprenaline
- L-Type Ca-2+-Channel
- Ventricular Myocytes
- Heart
- Patch-Clamp