Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Voortman, J; Goto, A; Mendiboure, J; Sohn, JJ; Schetter, AJ; Saito, M; Dunant, A; Pham, TC; Petrini, I; Lee, A; Khan, MA; Hainaut, P; Pignon, JP; Brambilla, E; Popper, HH; Filipits, M; Harris, CC; Giaccone, G.
MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non-Small Cell Lung Carcinoma.
Cancer Res. 2010; 70(21): 8288-8298. Doi: 10.1158/0008-5472.CAN-10-1348 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

Co-authors Med Uni Graz: Popper Helmuth
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: This study determined whether expression levels of a panel of biologically relevant microRNAs can be used as prognostic or predictive biomarkers in patients who participated in the International Adjuvant Lung Cancer Trial (IALT), the largest randomized study conducted to date of adjuvant chemotherapy in patients with radically resected non-small cell lung carcinoma (NSCLC). Expression of miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a was determined by quantitative real-time PCR in formalin-fixed paraffin-embedded tumor specimens from 639 IALT patients. The prognostic and predictive values of microRNA expression for survival were studied using a Cox model, which included every factor used in the stratified randomization, clinicopathologic prognostic factors, and other factors statistically related to microRNA expression. Investigation of the expression pattern of microRNAs in situ was performed. We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression. Finally, the association of p16 and miR-29b expression was assessed. Overall, no significant association was found between any of the tested microRNAs and survival, with the exception of miR-21 for which a deleterious prognostic effect of lowered expression was suggested. Otherwise, no single or combinatorial microRNA expression profile predicted response to adjuvant cisplatin-based chemotherapy. Together, our results indicate that the microRNA expression patterns examined were neither predictive nor prognostic in a large patient cohort with radically resected NSCLC, randomized to receive adjuvant cisplatin-based chemotherapy versus follow-up only.
Find related publications in this database (using NLM MeSH Indexing): Antineoplastic Agents - therapeutic use; Carcinoma, Non-Small-Cell Lung - drug therapy; Chemotherapy, Adjuvant -; Cisplatin - therapeutic use; Combined Modality Therapy -; Female -; Humans -; In Situ Hybridization -; Lung Neoplasms - drug therapy; Male -; MicroRNAs - genetics; Middle Aged -; Mutation - genetics; Neoplasm Invasiveness -; Paraffin Embedding -; Prognosis -; RNA, Messenger - genetics; Reverse Transcriptase Polymerase Chain Reaction -; Survival Rate -; Tumor Markers, Biological - genetics; Tumor Suppressor Protein p53 - genetics