Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bernecker, C; Pailer, S; Kieslinger, P; Horejsi, R; Möller, R; Lechner, A; Wallner-Blazek, M; Weiss, S; Fazekas, F; Truschnig-Wilders, M; Gruber, HJ.
GLP-2 and leptin are associated with hyperinsulinemia in non-obese female migraineurs.
Cephalalgia. 2010; 30(11): 1366-1374.
Doi: 10.1177/0333102410364674
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- Leading authors Med Uni Graz
- Bernecker Claudia
- Co-authors Med Uni Graz
- Fazekas Franz
- Gruber Hans-Jürgen
- Horejsi Renate
- Kieslinger Petra
- Lechner Anita
- Möller Reinhard
- Pailer Sabine
- Truschnig-Wilders Martini
- Wallner-Blazek Mirja
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- Abstract:
- Impaired insulin metabolism has been implicated in migraine. However, to date only some putative effects, especially regarding the involvement of adipocytokines and glucagon-like peptides (GLPs), have been described. The aim of the present study was to investigate adipocytokines and GLPs in non-obese female migraineurs. Various parameters of the insulin metabolism and body measurements were determined in 84 non-obese female subjects. We found highly significantly increased insulin levels with an odds ratio of 10.62 for migraine. Leptin and GLP-2 levels were also increased and correlated with insulin. Logistic regression analysis of leptin and GLP-2 revealed odds ratios of 3.79 and 4.26 for migraine, respectively, when comparing the lowest with the highest quartile of the test variable in the complete study cohort. We show that non-obese female migraineurs suffer from hyperinsulinemia, which is associated with elevated leptin and GLP-2 levels. Increased leptin and GLP-2 are risk factors for migraine. Our data suggest that migraine is associated with a higher risk for insulin resistance and its clinical consequences.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Body Mass Index -
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Glucagon-Like Peptide 2 - blood
- Humans -
- Hyperinsulinism - complications
- Leptin - blood
- Migraine Disorders - complications
- Risk Factors -
- Find related publications in this database (Keywords)
- migraine
- leptin
- GLP-2
- insulin