Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hauffa, BP; Knaup, K; Lehmann, N; Neudorf, U; Nagel, B.
Effects of growth hormone therapy on cardiac dimensions in children and adolescents with prader-willi syndrome.
Horm Res Paediatr. 2011; 75(1): 56-62.
Doi: 10.1159/000319612
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Nagel Bert Hermann Philipp
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- Abstract:
- Objectives: Growth hormone (GH) secretory status and GH therapy influence cardiac muscle mass and function. Most patients with Prader-Willi syndrome (PWS) are GH-deficient (GHD), and are at risk to develop obesity-related cardiac problems. Few data exist on the development of cardiac dimensions under GH treatment in PWS. Study Design: In a retrospective study, cardiac dimensions measured echocardiographically in 26 children with PWS before and after 22.9 +/- 11.0 months of GH therapy (0.035 mg/kg/day) were compared to those of 13 GHD children treated with GH (0.025-0.035 mg/kg/day) over 13.5 +/- 4.2 months. Results: Low-normal left ventricular end-systolic [diastolic] diameter SDS increased in PWS patients (1.41, p < 0.0001 [1.23, p < 0.0001]) and in controls (0.61, p = 0.04 [0.78, p = 0.013]), becoming elevated above normal in 2/26 PWS patients. There was a trend for a higher GH effect on left ventricular end-systolic diameter in PWS (p = 0.071). Mean values of all echocardiographic dimensions remained in the normal range in both PWS patients and controls, before and under GH therapy. Conclusion: The response of cardiac dimensions to GH treatment is similar in PWS patients and GHD controls, with a trend towards more elevated left ventricular parameters in PWS. Therefore, regular echocardiographic assessment may be considered in PWS children with longer treatment duration. Copyright (C) 2010 S. Karger AG, Basel
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